There are issues with teflon seals taking the shape of the guide when new, but after some miles on street cars, the sealing surface of the valve seal (the part that rides on the stem) still is fine. But the area that seals on the guide becomes stiff and does not seal well all the way around the guide... So it sucks oil up under the body and the sealing surface has no chance to work. I havent had that. But I've seen it happen. There is no such thing as stopping 100% of oil. with proper guide clearance, you will not sieze a giude. But proper means tight when you're talking teflon. If the valve can move around too much, as I said, the seal can't flex very well to keep sealing. If you're not installing bronze guides or liners, tefflon won't seal for long. Because the clearances with iron guides allows for too much movement for the positive seals to work with long term.
In my opinion, the viton seals are the best bet, but teflon will work fine if the machine work and parts are good.