With a 15x8" in the front you'll have to be careful with the backspacing. You'll need at least 4.5" to get it off the fender, but 5" is probably the max before you get into the tie rod, ball joint and UCA.
I run a 17x9" rim in the front, but since I have a 2" drop spindle my tie rod is basically in the same position it would be in relation to a 15" rim. I have 5" of BS, and only about 3/8" to between the tie rod and the lip of the rim. I run a 275/40/17, but its also only a 26" tall tire.
And as Brad pointed out, as you get close to the max your production tolerances really come into play. I had no issues at all with my driver's side, but on the passenger side I had to play with the ride height and roll the fender lip a little to get it to clear.