I run the Holley Blue and regulator, in a dead head system. It's -12 from sump to filter, filter to pump, -8 pump to regu;lator, and twin -6s to the bowls. That's enough to supply 500+hp easy. But, it's noisey, and I have a tank sump. If you're running a factory pickup, I would run the Carter or Mallory electric pump. IIRC they are 70gph. That's plenty for your setup, and they run quieter. As for line, if it's a street car, dont run aluminum. Every car is different, but I've seen a lot of leaks in teh past after some street miles. Both from impacts with road garbage and from chassis twisting. -6 is basically 3/8 ID, and wil lfeed it fine. I run mine up the frame, then thru the alignment cutout on the inner well. The regualtor is on the inner fender well flat spot, and the line comes up thru the body. Then the lines go to the carb. No boiling issues.