I use welding cable , available in 4 or 0 ga from Princess auto or other places , generally I have used 4 ga with no issues , flexable , well insulated & will carry serious current reliably I run 1 wire from the battery + to the main starter terminal Then run a 8 or 10 ga wire to the start relay from the same terminal , so you can jump to the distribution block instead & use a heavier jumper .
You do not have to eliminate all the factory fues but the extra fuse block is great fro supplying power to all the add ons .
I run the negative cable forward to the trans mount so there is no loss between the engine & battery , I also run a pigtail from the - terminal to the body for everything else to be grounded , I usually run a jumper from the engine block to the firewall .
Above is how I set up the Roadrunner , above all the stock power needs I added 2 electric fuel pumps 1 for each line dedicated to each rail of the EFI , we had 3 electric fans 2 pullers & a pusher , electric water pump , EFI computer , I added a 150 amp alt serpentine driven , & everything worked fine .
What you need to consider is most of the time the draw will be more like 80 amps as you will not need the electric fans most of the time , especially on the highway , so max draw is nessisary but not most of the time so battery cables should not heat up if they are 4ga