It can be done. I had good results spraying single stage EV2 on my car in my garage. Has the same amount of orange peel as today's production cars.
I've got a 3 car garage (double, single) and I setup a makeshift booth on the double side by attaching strips of 1x2 on the ceiling to attach plastic sheeting to. Made a "door" + frame out of the 1x2 as well for ease of entry/exit and wrapped that in plastic. Also a frame for the large intake fan and bank of exhaust fans with filters to go with all them. I anchored the plastic sheeting to the floor by wrapping it in 2x4s. Lots of shop lights outside of the plastic aimed at what I was spraying - the more the better.
Blow the ceiling, walls, car, and anything that could have dust - did that multiple times and different directions, get every nook and cranny.
Mop the floor - did that multiple times until I was satisfied the floor was as clean as I could get it.
Wipe down the car - did that 3 times.
I used a full spray suit (head to toe) I bought at HD and a borrowed supplied breathing system. If I didn't have the system, I would have used a mask with a _fresh_ filter that filters volatile organics for each spraying session. Don't want to mess around with VOCs and especially isocyanates - the isos are what get you sick.
Used 2 guns: a FLG4 for epoxy primer/sealer and high build, and a Sagola 4500 Xtreme for the color coat.
Watch the paint pot life and thoroughly clean the gun afterwards.
Plan your painting pattern in advance and watch your hoses.
For the hood, I'd position it horizontally like it were on the car using some saw horses. If it were hanging vertically, there would be a good chance of runs due to the large surface area.
Good luck!
