I run a 625 Carter AFB on my near stock 340 with a 4 speed. This carb is no longer available, but Edelbrock has a similar carb, a Thunder Series 650. My setup has plenty of power and gets 18 mpg on the freeway. I personally think the larger carbs tend to run a little rich and don't tune well especially near idle i.e. cruise night driving, etc. Both will work, but we all tend to go the hotrod magazine direction and end up overcarbureting. I might be wrong, but you may take a hit in the fuel mileage department with the bigger carb, which wasn't an issue until the gas price increases we've seen this year. Just my 2 cents worth.