Having identical issues with a 528 and dual quads, initially suspected ignition problems. Replaced my old points system with electronic first and didn't notice much of a change, if any at all. I just picked up a Holley blue electric pump and regulator to supplement my carter mechanical pump at WOT and I plan on running a new 3/8 fuel line to replace the old 5/16 line.... but the rear main seal failed over the weekend so the whole motor is coming out now. If I manage to get the whole thing put back together in a timely manner I'll try and post the results of the changes.
A couple things didn't get the chance to try yet before the failure were: insulating the fuel line between the pump and carb(s), eliminating the filter, and rejetting.
I know my valves aren't floating, because I accidentally winged it to 7k when the column shifter went between gears.