I am using the Edelbrock Pro-Flo EFI for the big block. It is port injected and likes a cam that is more on the high vacuum at idle side. It does not use a wide band O-2, so it is not self tuning. I have the 550 hp version and it runs very well. With the narrow band sensor you are able to drive from sea level to high up in the mountains then down again without having to stop and change any jets. I was able to get 20-22 mpg with my 440 and overdrive tranny, on the 06 Power Tour.
These days, Wide band is the way to go. You could stay at wide open throttle all d ay long and the WB-O-2 doesn't just tell the computer if it is rich or lean, it tells it how much it is rich or lean.
The top Picture is my Pro-Flo, the second pic is my homemade efi intake.