Ive spent a lot of time in Prague and the Czech country side. Last time I was there was a year ago. Ive been most of the interesting places and "lived" there on the weekends, while I was working in Germany.
Dont know what youre looking for but....
(st) King Wenceslaus and Jan Hus are major historical figures, Roman occupation...
Saint Vitus Cathedral in the castle is interesting as is the St Charles Bridge over the Vltava river, the the old Jewish center.
Prague (Praha) the golden city, Brno, Ceske Krumlov, Znojmo (for the wine, "see you twice in Znojmo"), Marianzke Lazne (spa town)
Budweiser Budvar beer (looks like a spitting image of the Budweiser label) and of course Pilsner Urquell and Staropramen,
Velvet revolution... So much Culture...
Prague is absolutely beautiful... as are the Czech women.