The ED heads are OK to use stock on a smaller motor if you check the valveguide clearance before running them. I've heard that some come a bit too tight. They flow about like ported J heads the way they come.
For a bigger motor over 400 cubes, I don't think the Intake valves are big enough and the port volume is inadequate, unless you're happy with a short winded grunt TQ motor that throws the anchor out at 5,000rpm. At high RPM you get little more cylinder filling than what is contained in each cylinders port, so the bigger the motor is the more port volume is needed to feed the motor. That's obviously a different requirement for a 340 than it is for 416. Even the BB Mope engines like the old 413 have 2.08" Intake valves, and they're thought to be on the small side for anything bigger than a 383. A wedge head can only flow a finite amount of air with a 2.02" valve.