I usually weld with my welder set on the following:
Wire speed 45
AMPS 1 or 2 for thin stuff
AMPS on 3-4 for plug welds... (Make sure you get penetration on all plug welds)
Like others have stated above, make sure the surface is clean of paint, oil and rust. If you use a rust preventive coating, make sure you use 3M weld thru primer. Regular primer will cause disaster and your welds will look like this
Stitch welding works the best and spread each tack weld out along the panel so you can keep coming back the each one and evenly distribute the heat as you work. I like to start my next stitch on part of the previous tack made (The metal is thicker here and less likely to blow out).
I am not an expert, but this seems to work for me. I learned on a set of floor pans that I installed by butt welding them in place. Lots of welding and grinding. Then, the new 1 piece pans became available and I replaced. Full panel replacement with plug welds is much easier to me and provides a much better result when finished.
Daniel
www.ebodyproducts.com