check for exhaust leaks around the engine and at the lower part of the exhaust sysem . a slight leak could cause this . second what fuel pump are you using ? what fuel pressure is the system set at ? does it happen only when you let off the throttle or does it seem to happen when under a load when at wide open throttle hotdogging it?
did you set the air fuel mixture with a vaccuum gauge ? is the float level set right , if its too low you can run into a lean condition .
ok now , what is you engine combo? cam , heads , intake , carb , ignition, fuel pump , exhaust , compression.
lotsof mixed questions , just trying to make you think . good luck -->Bill