Safety-wise, jack the back of the car up and put a strong jack stand under the frame just in front of the front spring mount on each side of the car. I don't know if its the best way, but I usually jack the back up using a floor jack under the center of the rear end lifting both sides at once to get it on the jack stands, if you're not on a flat floor chalk the front wheels first. I would replace the springs one side at a time keeping the jack under the rear-end center section to hold it up while you're working. Another way to do this is drop the back shackles on both at the same time and lower the rear to the floor. Then unbolt the front of the leaf springs and finish lowering the springs & the rear as one, take the springs loose from the rear. And then basically reassemble in reverse order. Problem with this method is that you're definitely going to have to unhook the rubber brake line from the rear which means you'll have to reconnect and bleed the brakes when you're done. You also will probaby want to disconnect the driveshaft to keep it from falling out of the trans. Lastly, whenever I take a wheel off to work on a car I always put it under the car where it could do the most good if it fell off the jack(s). I'm not sure if this is what you meant by how to do this safely, but however you do it take every precaution & stay safe!
Later, Jim