Normally, the problem with a cooling system comes from either too little coolant flow or too little air flow.
With regard to too little coolant flow, we know there are some water pumps out there that have small passages that restrict water flow. The 440 Source unit is one that has been reported thus...and some thermostats open slowly and don't open substantially at their rated temps. If you have a high flow thermostat, you need to also have a good high flow pump that will build sufficient pressure in the engine to eliminate hot spots that will create localized boiling in the engine. This then pushes steam bubbles into the coolant which reduces heat transfer.
On the air flow side, we can have a good radiator and block air flow at speed due to an improperly designed shroud that does not let the air out the back side of the core. Some electric fan shrouds are bad about this. The volume is too small due to a shallow depth in the shroud which tends to brick wall the airflow that comes in the front. If you look at Sledge's pictures, he has two 14" fans that cover much of the surface area of the radiator and the shroud does not serve as an air block. If it had two 10-11" fans, then it would have a far greater difficulty in passing air thru at highway speeds. We also have the problem in that all fans may not be rated at the same head pressures so that the cfm ratings may not truly be comparable in a given usage. Normally, good, high volume fans cost a lot more money than do cheaper fans even if the ratings are similar. The amperage ratings of the fan can often be a better indicator than the factory rating of cfm.
At highway speeds, the car should run cool even without a fan or fans if the radiator is of sufficient size and they are sealed to the radiator opening so that air must go thru the core instead of finding a path around it.
Normally, a quality aluminum radiator of sufficient size will do a better job of cooling than well a factory non-aluminum unit due to the larger tubes that present much greater surface area to the air flow in spite of aluminum's lower coefficient of heat transfer.