What initial timing are you running? If it has a long duration cam, it will probably make its best vacuum with at least 16 degs of timing for initial. If you are not running in that vincinity, then bump it up and see what happens.
If that makes a major improvement, then you will have to follow the above advice and check the total timing, and then make any required changes to the mechanical advance so that you can run 16 initial with the total in the 36-38 deg range as suggested above.
You did not say if the above was taken in gear if the car is an automatic or in park/neutral. If a stick, I am assuming that is in neutral or clutch in. If it is an auto, what stall converter are you running?
It would really be nice to know the cam duration to be able to make some assumption.
Adusting the mix adjust screws can make a little difference, but seldom a big number in most cases.